Enhancing Gene-Knockdown Efficiency of Poly(N-isopropylacrylamide) Nanogels

Polymeric Nanogels as Gene Carriers

Polyn ô mes

1.1 Définitions élémentaires Définition 1. Soit P ∈ k[X ] et a ∈ k. On dit que a est une racine de P si P (a) = 0, ou de manière équivalente si X − a divise P . On appelle multiplicité de a le plus grand entier μ tel que (X − a) divise P . Proposition 1. Si P ∈ k[X ] admet a1, . . . , al pour racines, de multiplicités respectives μ1, . . . , μl, alors il existe Q ∈ k[X ] tel que P = Q∏(X − ai)i...

assessment of the efficiency of s.p.g.c refineries using network dea

data envelopment analysis (dea) is a powerful tool for measuring relative efficiency of organizational units referred to as decision making units (dmus). in most cases dmus have network structures with internal linking activities. traditional dea models, however, consider dmus as black boxes with no regard to their linking activities and therefore do not provide decision makers with the reasons...

Characterization of complexation of poly (N-isopropylacrylamide-co-2-(dimethylamino) ethyl methacrylate) thermoresponsive cationic nanogels with salmon sperm DNA

Thermoresponsive cationic nanogel (TCNG) networks based on N-isopropylacrylamide (NIPAM), 2-(dimethylamino)ethyl methacrylate (DMAEMA), and quaternary alkyl ammonium halide salts of DMAEMA (DMAEMAQ) were synthesized by dispersion polymerization technique. The thermoresponsive properties of TCNGs and TCNG-salmon sperm DNA (sasDNA) polyplexes were characterized in aqueous media of various pH and ...

Enhancing Adult Nerve Regeneration through the Knockdown of Retinoblastoma Protein

Tumour suppressor pathways may offer novel targets capable of altering the plasticity of post-mitotic adult neurons. Here we describe a role for the retinoblastoma (Rb) protein, widely expressed in adult sensory neurons and their axons, during regeneration. In adult sensory neurons, Rb short interfering RNA (siRNA) knockdown or Rb1 deletion in vitro enhances neurite outgrowth and branching. Pla...